FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDF0128, 1519 aa 1>>>pF1KSDF0128 1519 - 1519 aa - 1519 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.5444+/-0.000381; mu= 6.3585+/- 0.024 mean_var=304.6637+/-63.765, 0's: 0 Z-trim(122.9): 234 B-trim: 2180 in 2/57 Lambda= 0.073479 statistics sampled from 41584 (41876) to 41584 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.776), E-opt: 0.2 (0.491), width: 16 Scan time: 22.480 The best scores are: opt bits E(85289) NP_060541 (OMIM: 610018) rho guanine nucleotide ex (1519) 10331 1110.1 0 XP_011535239 (OMIM: 610018) PREDICTED: rho guanine (1523) 10313 1108.2 0 XP_005267901 (OMIM: 610018) PREDICTED: rho guanine (1471) 9664 1039.4 0 XP_016876923 (OMIM: 610018) PREDICTED: rho guanine (1331) 8976 966.4 0 XP_011535240 (OMIM: 610018) PREDICTED: rho guanine ( 924) 6024 653.3 2.6e-186 NP_001265458 (OMIM: 610018) rho guanine nucleotide ( 805) 5378 584.7 9.8e-166 XP_016876924 (OMIM: 610018) PREDICTED: rho guanine ( 809) 5360 582.8 3.7e-165 XP_016876925 (OMIM: 610018) PREDICTED: rho guanine ( 809) 5360 582.8 3.7e-165 XP_016876926 (OMIM: 610018) PREDICTED: rho guanine ( 757) 4711 514.0 1.8e-144 NP_001265459 (OMIM: 610018) rho guanine nucleotide ( 757) 4711 514.0 1.8e-144 NP_001123199 (OMIM: 609526) puratrophin-1 isoform (1191) 1182 140.1 1e-31 NP_001123201 (OMIM: 609526) puratrophin-1 isoform (1191) 1182 140.1 1e-31 XP_011521289 (OMIM: 609526) PREDICTED: puratrophin (1191) 1182 140.1 1e-31 XP_011521287 (OMIM: 609526) PREDICTED: puratrophin (1191) 1182 140.1 1e-31 XP_011521290 (OMIM: 609526) PREDICTED: puratrophin (1191) 1182 140.1 1e-31 XP_011521288 (OMIM: 609526) PREDICTED: puratrophin (1191) 1182 140.1 1e-31 NP_001123200 (OMIM: 609526) puratrophin-1 isoform (1191) 1182 140.1 1e-31 NP_001123203 (OMIM: 609526) puratrophin-1 isoform (1110) 1123 133.8 7.5e-30 NP_001309925 (OMIM: 604605,608901) kalirin isoform ( 700) 380 54.9 2.8e-06 NP_001309924 (OMIM: 604605,608901) kalirin isoform ( 701) 380 54.9 2.8e-06 NP_001309926 (OMIM: 604605,608901) kalirin isoform ( 699) 378 54.6 3.2e-06 NP_001309922 (OMIM: 604605,608901) kalirin isoform (1288) 380 55.1 4.3e-06 NP_008995 (OMIM: 604605,608901) kalirin isoform 3 (1289) 380 55.1 4.3e-06 NP_001309930 (OMIM: 604605,608901) kalirin isoform ( 667) 364 53.1 8.7e-06 NP_001309929 (OMIM: 604605,608901) kalirin isoform ( 668) 364 53.1 8.7e-06 NP_001309928 (OMIM: 604605,608901) kalirin isoform ( 668) 364 53.1 8.7e-06 NP_001309927 (OMIM: 604605,608901) kalirin isoform ( 669) 364 53.1 8.7e-06 NP_001309921 (OMIM: 604605,608901) kalirin isoform (1613) 334 50.3 0.00015 NP_001309920 (OMIM: 604605,608901) kalirin isoform (1641) 334 50.4 0.00015 XP_016862924 (OMIM: 604605,608901) PREDICTED: kali (1643) 334 50.4 0.00015 NP_001309919 (OMIM: 604605,608901) kalirin isoform (1650) 334 50.4 0.00015 XP_016862923 (OMIM: 604605,608901) PREDICTED: kali (1652) 334 50.4 0.00015 NP_001309918 (OMIM: 604605,608901) kalirin isoform (1654) 334 50.4 0.00015 XP_016862922 (OMIM: 604605,608901) PREDICTED: kali (1656) 334 50.4 0.00015 NP_003938 (OMIM: 604605,608901) kalirin isoform 2 (1663) 334 50.4 0.00015 XP_006713878 (OMIM: 604605,608901) PREDICTED: kali (1665) 334 50.4 0.00015 XP_016862921 (OMIM: 604605,608901) PREDICTED: kali (2366) 336 50.7 0.00017 XP_011511587 (OMIM: 604605,608901) PREDICTED: kali (2367) 336 50.7 0.00017 NP_001309917 (OMIM: 604605,608901) kalirin isoform (2396) 336 50.7 0.00017 XP_016862920 (OMIM: 604605,608901) PREDICTED: kali (2398) 336 50.7 0.00017 XP_011511585 (OMIM: 604605,608901) PREDICTED: kali (2401) 336 50.7 0.00017 XP_016862919 (OMIM: 604605,608901) PREDICTED: kali (2955) 336 50.8 0.00019 XP_006713877 (OMIM: 604605,608901) PREDICTED: kali (2956) 336 50.8 0.00019 XP_006713876 (OMIM: 604605,608901) PREDICTED: kali (2966) 336 50.8 0.00019 XP_016862918 (OMIM: 604605,608901) PREDICTED: kali (2968) 336 50.8 0.00019 XP_006713875 (OMIM: 604605,608901) PREDICTED: kali (2975) 336 50.8 0.00019 XP_011511583 (OMIM: 604605,608901) PREDICTED: kali (2977) 336 50.8 0.00019 XP_006713874 (OMIM: 604605,608901) PREDICTED: kali (2979) 336 50.8 0.00019 NP_001019831 (OMIM: 604605,608901) kalirin isoform (2986) 336 50.8 0.00019 XP_011511582 (OMIM: 604605,608901) PREDICTED: kali (2987) 336 50.8 0.00019 >>NP_060541 (OMIM: 610018) rho guanine nucleotide exchan (1519 aa) initn: 10331 init1: 10331 opt: 10331 Z-score: 5930.6 bits: 1110.1 E(85289): 0 Smith-Waterman score: 10331; 99.9% identity (99.9% similar) in 1519 aa overlap (1-1519:1-1519) 10 20 30 40 50 60 pF1KSD MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHLGEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: NP_060 AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPSSKGSMEAGPYL :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: NP_060 FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KSD TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KSD LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KSD ACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGI 1450 1460 1470 1480 1490 1500 1510 pF1KSD LGLSRQSHARALSDPTTPL ::::::::::::::::::: NP_060 LGLSRQSHARALSDPTTPL 1510 >>XP_011535239 (OMIM: 610018) PREDICTED: rho guanine nuc (1523 aa) initn: 9952 init1: 9952 opt: 10313 Z-score: 5920.3 bits: 1108.2 E(85289): 0 Smith-Waterman score: 10313; 99.6% identity (99.7% similar) in 1523 aa overlap (1-1519:1-1523) 10 20 30 40 50 60 pF1KSD MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHLGEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_011 AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPSSKGSMEAGPYL :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_011 FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KSD TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KSD LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KSD ACSLPARVEEEAWDLDVKQISLA----PETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLA ::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: XP_011 ACSLPARVEEEAWDLDVKQISLASPSAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLA 1450 1460 1470 1480 1490 1500 1500 1510 pF1KSD SRGILGLSRQSHARALSDPTTPL ::::::::::::::::::::::: XP_011 SRGILGLSRQSHARALSDPTTPL 1510 1520 >>XP_005267901 (OMIM: 610018) PREDICTED: rho guanine nuc (1471 aa) initn: 9729 init1: 9642 opt: 9664 Z-score: 5548.7 bits: 1039.4 E(85289): 0 Smith-Waterman score: 9911; 96.7% identity (96.8% similar) in 1519 aa overlap (1-1519:1-1471) 10 20 30 40 50 60 pF1KSD MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHLGEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_005 AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPSSKGSMEAGPYL :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_005 FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KSD TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KSD LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG ::::::::::::::::::::::::::::::::::: XP_005 LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRA------------------------- 1390 1400 1410 1450 1460 1470 1480 1490 1500 pF1KSD ACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGI ::::::::::::::::::::::::::::::::::::: XP_005 -----------------------PETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGI 1420 1430 1440 1450 1510 pF1KSD LGLSRQSHARALSDPTTPL ::::::::::::::::::: XP_005 LGLSRQSHARALSDPTTPL 1460 1470 >>XP_016876923 (OMIM: 610018) PREDICTED: rho guanine nuc (1331 aa) initn: 8615 init1: 8615 opt: 8976 Z-score: 5155.0 bits: 966.4 E(85289): 0 Smith-Waterman score: 8976; 99.5% identity (99.6% similar) in 1331 aa overlap (193-1519:1-1331) 170 180 190 200 210 220 pF1KSD STCLLSAPSGIQRLPWAELICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEAL :::::::::::::::::::::::::::::: XP_016 MVGHQPSTLPPELPSGPPGLPSPPLPEEAL 10 20 30 230 240 250 260 270 280 pF1KSD GTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGR 40 50 60 70 80 90 290 300 310 320 330 340 pF1KSD HRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVG 100 110 120 130 140 150 350 360 370 380 390 400 pF1KSD EASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSP 160 170 180 190 200 210 410 420 430 440 450 460 pF1KSD GDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEAC 220 230 240 250 260 270 470 480 490 500 510 520 pF1KSD GPTEEGAGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPTEEGAGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSD 280 290 300 310 320 330 530 540 550 560 570 580 pF1KSD HPDVAWDLMASGFLILTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPDVAWDLMASGFLILTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPD 340 350 360 370 380 390 590 600 610 620 630 640 pF1KSD LQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAE 400 410 420 430 440 450 650 660 670 680 690 700 pF1KSD VLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELE 460 470 480 490 500 510 710 720 730 740 750 760 pF1KSD GAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEV 520 530 540 550 560 570 770 780 790 800 810 820 pF1KSD DEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETEL 580 590 600 610 620 630 830 840 850 860 870 880 pF1KSD RFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAH 640 650 660 670 680 690 890 900 910 920 930 940 pF1KSD EWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQ 700 710 720 730 740 750 950 960 970 980 990 1000 pF1KSD ARCQELERRIQQHLGEEASPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRP :::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARCQELERRIQQHVGEEASPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRP 760 770 780 790 800 810 1010 1020 1030 1040 1050 1060 pF1KSD APSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGR 820 830 840 850 860 870 1070 1080 1090 1100 1110 1120 pF1KSD ARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGT 880 890 900 910 920 930 1130 1140 1150 1160 1170 1180 pF1KSD WAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENG 940 950 960 970 980 990 1190 1200 1210 1220 1230 1240 pF1KSD LAALSPSSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQL :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQL 1000 1010 1020 1030 1040 1050 1250 1260 1270 1280 1290 1300 pF1KSD LREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSK 1060 1070 1080 1090 1100 1110 1310 1320 1330 1340 1350 1360 pF1KSD LKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLK 1120 1130 1140 1150 1160 1170 1370 1380 1390 1400 1410 1420 pF1KSD WTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASV 1180 1190 1200 1210 1220 1230 1430 1440 1450 1460 1470 pF1KSD AVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLA----PETLDSSGDVSPGPR ::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_016 AVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLASPSAPETLDSSGDVSPGPR 1240 1250 1260 1270 1280 1290 1480 1490 1500 1510 pF1KSD NSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL ::::::::::::::::::::::::::::::::::::::::: XP_016 NSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL 1300 1310 1320 1330 >>XP_011535240 (OMIM: 610018) PREDICTED: rho guanine nuc (924 aa) initn: 6024 init1: 6024 opt: 6024 Z-score: 3465.8 bits: 653.3 E(85289): 2.6e-186 Smith-Waterman score: 6024; 100.0% identity (100.0% similar) in 881 aa overlap (1-881:1-881) 10 20 30 40 50 60 pF1KSD MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE ::::::::::::::::::::::::::::::::::::::::: XP_011 ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQALPSPYQLRVTWLGSDGGTV 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHLGEEA XP_011 RKQESDGHWEATGKRTRAVTGHPS 910 920 >>NP_001265458 (OMIM: 610018) rho guanine nucleotide exc (805 aa) initn: 5378 init1: 5378 opt: 5378 Z-score: 3096.4 bits: 584.7 E(85289): 9.8e-166 Smith-Waterman score: 5378; 99.8% identity (99.9% similar) in 805 aa overlap (715-1519:1-805) 690 700 710 720 730 740 pF1KSD RLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRS :::::::::::::::::::::::::::::: NP_001 MPKPLQKVLADPRLTALQRDGGAILMRLRS 10 20 30 750 760 770 780 790 800 pF1KSD TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQL 40 50 60 70 80 90 810 820 830 840 850 860 pF1KSD ASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQV 100 110 120 130 140 150 870 880 890 900 910 920 pF1KSD ESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRA 160 170 180 190 200 210 930 940 950 960 970 980 pF1KSD LALDLGSPAALREWGRCQARCQELERRIQQHLGEEASPRGYRRRRADGASSGGAQWGPRS :::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::: NP_001 LALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASSGGAQWGPRS 220 230 240 250 260 270 990 1000 1010 1020 1030 1040 pF1KSD PSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTS 280 290 300 310 320 330 1050 1060 1070 1080 1090 1100 pF1KSD TEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATL 340 350 360 370 380 390 1110 1120 1130 1140 1150 1160 pF1KSD SEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGD 400 410 420 430 440 450 1170 1180 1190 1200 1210 1220 pF1KSD QFSLYAQYVKHRHKLENGLAALSPSSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLRE :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: NP_001 QFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLRE 460 470 480 490 500 510 1230 1240 1250 1260 1270 1280 pF1KSD AGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGR 520 530 540 550 560 570 1290 1300 1310 1320 1330 1340 pF1KSD KKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRR 580 590 600 610 620 630 1350 1360 1370 1380 1390 1400 pF1KSD RAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGE 640 650 660 670 680 690 1410 1420 1430 1440 1450 1460 pF1KSD RTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAP 700 710 720 730 740 750 1470 1480 1490 1500 1510 pF1KSD ETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL 760 770 780 790 800 >>XP_016876924 (OMIM: 610018) PREDICTED: rho guanine nuc (809 aa) initn: 4999 init1: 4999 opt: 5360 Z-score: 3086.1 bits: 582.8 E(85289): 3.7e-165 Smith-Waterman score: 5360; 99.3% identity (99.4% similar) in 809 aa overlap (715-1519:1-809) 690 700 710 720 730 740 pF1KSD RLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRS :::::::::::::::::::::::::::::: XP_016 MPKPLQKVLADPRLTALQRDGGAILMRLRS 10 20 30 750 760 770 780 790 800 pF1KSD TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQL 40 50 60 70 80 90 810 820 830 840 850 860 pF1KSD ASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQV 100 110 120 130 140 150 870 880 890 900 910 920 pF1KSD ESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRA 160 170 180 190 200 210 930 940 950 960 970 980 pF1KSD LALDLGSPAALREWGRCQARCQELERRIQQHLGEEASPRGYRRRRADGASSGGAQWGPRS :::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::: XP_016 LALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASSGGAQWGPRS 220 230 240 250 260 270 990 1000 1010 1020 1030 1040 pF1KSD PSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTS 280 290 300 310 320 330 1050 1060 1070 1080 1090 1100 pF1KSD TEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATL 340 350 360 370 380 390 1110 1120 1130 1140 1150 1160 pF1KSD SEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGD 400 410 420 430 440 450 1170 1180 1190 1200 1210 1220 pF1KSD QFSLYAQYVKHRHKLENGLAALSPSSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLRE :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: XP_016 QFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLRE 460 470 480 490 500 510 1230 1240 1250 1260 1270 1280 pF1KSD AGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGR 520 530 540 550 560 570 1290 1300 1310 1320 1330 1340 pF1KSD KKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRR 580 590 600 610 620 630 1350 1360 1370 1380 1390 1400 pF1KSD RAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGE 640 650 660 670 680 690 1410 1420 1430 1440 1450 1460 pF1KSD RTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLA- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAS 700 710 720 730 740 750 1470 1480 1490 1500 1510 pF1KSD ---PETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL 760 770 780 790 800 >>XP_016876925 (OMIM: 610018) PREDICTED: rho guanine nuc (809 aa) initn: 4999 init1: 4999 opt: 5360 Z-score: 3086.1 bits: 582.8 E(85289): 3.7e-165 Smith-Waterman score: 5360; 99.3% identity (99.4% similar) in 809 aa overlap (715-1519:1-809) 690 700 710 720 730 740 pF1KSD RLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRS :::::::::::::::::::::::::::::: XP_016 MPKPLQKVLADPRLTALQRDGGAILMRLRS 10 20 30 750 760 770 780 790 800 pF1KSD TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQL 40 50 60 70 80 90 810 820 830 840 850 860 pF1KSD ASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQV 100 110 120 130 140 150 870 880 890 900 910 920 pF1KSD ESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRA 160 170 180 190 200 210 930 940 950 960 970 980 pF1KSD LALDLGSPAALREWGRCQARCQELERRIQQHLGEEASPRGYRRRRADGASSGGAQWGPRS :::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::: XP_016 LALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASSGGAQWGPRS 220 230 240 250 260 270 990 1000 1010 1020 1030 1040 pF1KSD PSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTS 280 290 300 310 320 330 1050 1060 1070 1080 1090 1100 pF1KSD TEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATL 340 350 360 370 380 390 1110 1120 1130 1140 1150 1160 pF1KSD SEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGD 400 410 420 430 440 450 1170 1180 1190 1200 1210 1220 pF1KSD QFSLYAQYVKHRHKLENGLAALSPSSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLRE :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: XP_016 QFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLRE 460 470 480 490 500 510 1230 1240 1250 1260 1270 1280 pF1KSD AGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGR 520 530 540 550 560 570 1290 1300 1310 1320 1330 1340 pF1KSD KKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRR 580 590 600 610 620 630 1350 1360 1370 1380 1390 1400 pF1KSD RAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGE 640 650 660 670 680 690 1410 1420 1430 1440 1450 1460 pF1KSD RTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLA- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAS 700 710 720 730 740 750 1470 1480 1490 1500 1510 pF1KSD ---PETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL 760 770 780 790 800 >>XP_016876926 (OMIM: 610018) PREDICTED: rho guanine nuc (757 aa) initn: 4811 init1: 4689 opt: 4711 Z-score: 2714.7 bits: 514.0 E(85289): 1.8e-144 Smith-Waterman score: 4958; 93.8% identity (93.9% similar) in 805 aa overlap (715-1519:1-757) 690 700 710 720 730 740 pF1KSD RLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRS :::::::::::::::::::::::::::::: XP_016 MPKPLQKVLADPRLTALQRDGGAILMRLRS 10 20 30 750 760 770 780 790 800 pF1KSD TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQL 40 50 60 70 80 90 810 820 830 840 850 860 pF1KSD ASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQV 100 110 120 130 140 150 870 880 890 900 910 920 pF1KSD ESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRA 160 170 180 190 200 210 930 940 950 960 970 980 pF1KSD LALDLGSPAALREWGRCQARCQELERRIQQHLGEEASPRGYRRRRADGASSGGAQWGPRS :::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::: XP_016 LALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASSGGAQWGPRS 220 230 240 250 260 270 990 1000 1010 1020 1030 1040 pF1KSD PSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTS 280 290 300 310 320 330 1050 1060 1070 1080 1090 1100 pF1KSD TEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATL 340 350 360 370 380 390 1110 1120 1130 1140 1150 1160 pF1KSD SEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGD 400 410 420 430 440 450 1170 1180 1190 1200 1210 1220 pF1KSD QFSLYAQYVKHRHKLENGLAALSPSSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLRE :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: XP_016 QFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLRE 460 470 480 490 500 510 1230 1240 1250 1260 1270 1280 pF1KSD AGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGR 520 530 540 550 560 570 1290 1300 1310 1320 1330 1340 pF1KSD KKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRR 580 590 600 610 620 630 1350 1360 1370 1380 1390 1400 pF1KSD RAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGE 640 650 660 670 680 690 1410 1420 1430 1440 1450 1460 pF1KSD RTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAP ::::::::::: : XP_016 RTLSALLTGRA------------------------------------------------P 700 1470 1480 1490 1500 1510 pF1KSD ETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL 710 720 730 740 750 >>NP_001265459 (OMIM: 610018) rho guanine nucleotide exc (757 aa) initn: 4811 init1: 4689 opt: 4711 Z-score: 2714.7 bits: 514.0 E(85289): 1.8e-144 Smith-Waterman score: 4958; 93.8% identity (93.9% similar) in 805 aa overlap (715-1519:1-757) 690 700 710 720 730 740 pF1KSD RLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRS :::::::::::::::::::::::::::::: NP_001 MPKPLQKVLADPRLTALQRDGGAILMRLRS 10 20 30 750 760 770 780 790 800 pF1KSD TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQL 40 50 60 70 80 90 810 820 830 840 850 860 pF1KSD ASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQV 100 110 120 130 140 150 870 880 890 900 910 920 pF1KSD ESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRA 160 170 180 190 200 210 930 940 950 960 970 980 pF1KSD LALDLGSPAALREWGRCQARCQELERRIQQHLGEEASPRGYRRRRADGASSGGAQWGPRS :::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::: NP_001 LALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASSGGAQWGPRS 220 230 240 250 260 270 990 1000 1010 1020 1030 1040 pF1KSD PSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTS 280 290 300 310 320 330 1050 1060 1070 1080 1090 1100 pF1KSD TEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATL 340 350 360 370 380 390 1110 1120 1130 1140 1150 1160 pF1KSD SEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGD 400 410 420 430 440 450 1170 1180 1190 1200 1210 1220 pF1KSD QFSLYAQYVKHRHKLENGLAALSPSSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLRE :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: NP_001 QFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLRE 460 470 480 490 500 510 1230 1240 1250 1260 1270 1280 pF1KSD AGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGR 520 530 540 550 560 570 1290 1300 1310 1320 1330 1340 pF1KSD KKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRR 580 590 600 610 620 630 1350 1360 1370 1380 1390 1400 pF1KSD RAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGE 640 650 660 670 680 690 1410 1420 1430 1440 1450 1460 pF1KSD RTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAP ::::::::::: : NP_001 RTLSALLTGRA------------------------------------------------P 700 1470 1480 1490 1500 1510 pF1KSD ETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL 710 720 730 740 750 1519 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:24:21 2016 done: Thu Nov 3 19:24:24 2016 Total Scan time: 22.480 Total Display time: 0.570 Function used was FASTA [36.3.4 Apr, 2011]