FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDF0168, 567 aa 1>>>pF1KSDF0168 567 - 567 aa - 567 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4451+/-0.000356; mu= 18.4035+/- 0.022 mean_var=74.5573+/-15.341, 0's: 0 Z-trim(114.7): 51 B-trim: 1365 in 1/49 Lambda= 0.148535 statistics sampled from 24605 (24659) to 24605 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.289), width: 16 Scan time: 9.870 The best scores are: opt bits E(85289) NP_690863 (OMIM: 609742) L-amino-acid oxidase isof ( 567) 3817 827.5 0 NP_001244947 (OMIM: 609742) L-amino-acid oxidase i ( 589) 3793 822.4 0 NP_758962 (OMIM: 609742) L-amino-acid oxidase isof ( 589) 3793 822.4 0 NP_001244946 (OMIM: 609742) L-amino-acid oxidase i ( 589) 3793 822.4 0 NP_000889 (OMIM: 309860) amine oxidase [flavin-con ( 520) 400 95.3 5.3e-19 NP_000231 (OMIM: 300615,309850) amine oxidase [fla ( 527) 356 85.8 3.7e-16 XP_016885013 (OMIM: 309860) PREDICTED: amine oxida ( 504) 352 85.0 6.4e-16 XP_005272665 (OMIM: 309860) PREDICTED: amine oxida ( 504) 352 85.0 6.4e-16 XP_016885012 (OMIM: 309860) PREDICTED: amine oxida ( 504) 352 85.0 6.4e-16 NP_787034 (OMIM: 615854) spermine oxidase isoform ( 502) 233 59.5 3e-08 NP_787036 (OMIM: 615854) spermine oxidase isoform ( 532) 233 59.5 3.2e-08 NP_001257387 (OMIM: 300615,309850) amine oxidase [ ( 394) 223 57.3 1.1e-07 NP_001009999 (OMIM: 609132,616728) lysine-specific ( 876) 193 51.1 1.8e-05 XP_016856206 (OMIM: 609132,616728) PREDICTED: lysi ( 802) 187 49.7 4.1e-05 XP_016856205 (OMIM: 609132,616728) PREDICTED: lysi ( 822) 187 49.8 4.2e-05 XP_006710536 (OMIM: 609132,616728) PREDICTED: lysi ( 828) 187 49.8 4.2e-05 NP_055828 (OMIM: 609132,616728) lysine-specific hi ( 852) 187 49.8 4.3e-05 XP_006710535 (OMIM: 609132,616728) PREDICTED: lysi ( 858) 187 49.8 4.3e-05 XP_005245843 (OMIM: 609132,616728) PREDICTED: lysi ( 872) 187 49.8 4.4e-05 XP_006710537 (OMIM: 609132,616728) PREDICTED: lysi ( 878) 187 49.8 4.4e-05 NP_787035 (OMIM: 615854) spermine oxidase isoform ( 190) 173 46.3 0.0001 XP_005248985 (OMIM: 613081) PREDICTED: lysine-spec ( 678) 177 47.6 0.00016 XP_011512688 (OMIM: 613081) PREDICTED: lysine-spec ( 690) 177 47.6 0.00016 XP_011512687 (OMIM: 613081) PREDICTED: lysine-spec ( 691) 177 47.6 0.00016 XP_016865934 (OMIM: 613081) PREDICTED: lysine-spec ( 700) 177 47.6 0.00016 XP_016865931 (OMIM: 613081) PREDICTED: lysine-spec ( 802) 177 47.6 0.00018 XP_005248983 (OMIM: 613081) PREDICTED: lysine-spec ( 822) 177 47.6 0.00019 XP_005248982 (OMIM: 613081) PREDICTED: lysine-spec ( 823) 177 47.6 0.00019 XP_016865930 (OMIM: 613081) PREDICTED: lysine-spec ( 831) 177 47.6 0.00019 XP_016865932 (OMIM: 613081) PREDICTED: lysine-spec ( 832) 177 47.6 0.00019 XP_016865929 (OMIM: 613081) PREDICTED: lysine-spec ( 832) 177 47.6 0.00019 XP_016865935 (OMIM: 613081) PREDICTED: lysine-spec ( 464) 153 42.3 0.0041 NP_694587 (OMIM: 613081) lysine-specific histone d ( 590) 153 42.4 0.005 XP_016856209 (OMIM: 609132,616728) PREDICTED: lysi ( 551) 151 41.9 0.0064 XP_016856208 (OMIM: 609132,616728) PREDICTED: lysi ( 551) 151 41.9 0.0064 XP_016856207 (OMIM: 609132,616728) PREDICTED: lysi ( 557) 151 41.9 0.0064 >>NP_690863 (OMIM: 609742) L-amino-acid oxidase isoform (567 aa) initn: 3817 init1: 3817 opt: 3817 Z-score: 4418.9 bits: 827.5 E(85289): 0 Smith-Waterman score: 3817; 100.0% identity (100.0% similar) in 567 aa overlap (1-567:1-567) 10 20 30 40 50 60 pF1KSD MAPLALHLLVLVPILLSLVASQDWKAERSQDPFEKCMQDPDYEQLLKVVTWGLNRTLKPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 MAPLALHLLVLVPILLSLVASQDWKAERSQDPFEKCMQDPDYEQLLKVVTWGLNRTLKPQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFTYRDQNTGWIGELGAMRMPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 RVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFTYRDQNTGWIGELGAMRMPSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD HRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYVVEKVPEKLGYALRPQEKGHSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 HRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYVVEKVPEKLGYALRPQEKGHSPE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD DIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGEGNLSRPAVQLLGDVMSEDGFFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 DIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGEGNLSRPAVQLLGDVMSEDGFFY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 LSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD IETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPRHMQEALRRLHYVPATKVFLSFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 IETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPRHMQEALRRLHYVPATKVFLSFR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD RPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASYTWSDAAAAFAGLSREEALRLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 RPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASYTWSDAAAAFAGLSREEALRLAL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD DDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQPPALWQTEKDDWTVPYGRIYFAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 DDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQPPALWQTEKDDWTVPYGRIYFAG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD EHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPEGHASDMEGQGHVHGVASSPSHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_690 EHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPEGHASDMEGQGHVHGVASSPSHD 490 500 510 520 530 540 550 560 pF1KSD LAKEEGSHPPVQGQLSLQNTTHTRTSH ::::::::::::::::::::::::::: NP_690 LAKEEGSHPPVQGQLSLQNTTHTRTSH 550 560 >>NP_001244947 (OMIM: 609742) L-amino-acid oxidase isofo (589 aa) initn: 3793 init1: 3793 opt: 3793 Z-score: 4390.9 bits: 822.4 E(85289): 0 Smith-Waterman score: 3793; 99.6% identity (99.8% similar) in 565 aa overlap (3-567:25-589) 10 20 30 pF1KSD MAPLALHLLVLVPILLSLVASQDWKAERSQDPFEKCMQ : .::::::::::::::::::::::::::::::::: NP_001 MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVASQDWKAERSQDPFEKCMQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KSD DPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRI 70 80 90 100 110 120 100 110 120 130 140 150 pF1KSD FTYRDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTYRDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYV 130 140 150 160 170 180 160 170 180 190 200 210 pF1KSD VEKVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEKVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGE 190 200 210 220 230 240 220 230 240 250 260 270 pF1KSD GNLSRPAVQLLGDVMSEDGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNLSRPAVQLLGDVMSEDGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KSD GLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPR 310 320 330 340 350 360 340 350 360 370 380 390 pF1KSD HMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASY 370 380 390 400 410 420 400 410 420 430 440 450 pF1KSD TWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQP 430 440 450 460 470 480 460 470 480 490 500 510 pF1KSD PALWQTEKDDWTVPYGRIYFAGEHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PALWQTEKDDWTVPYGRIYFAGEHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPE 490 500 510 520 530 540 520 530 540 550 560 pF1KSD GHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH 550 560 570 580 >>NP_758962 (OMIM: 609742) L-amino-acid oxidase isoform (589 aa) initn: 3793 init1: 3793 opt: 3793 Z-score: 4390.9 bits: 822.4 E(85289): 0 Smith-Waterman score: 3793; 99.6% identity (99.8% similar) in 565 aa overlap (3-567:25-589) 10 20 30 pF1KSD MAPLALHLLVLVPILLSLVASQDWKAERSQDPFEKCMQ : .::::::::::::::::::::::::::::::::: NP_758 MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVASQDWKAERSQDPFEKCMQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KSD DPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 DPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRI 70 80 90 100 110 120 100 110 120 130 140 150 pF1KSD FTYRDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 FTYRDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYV 130 140 150 160 170 180 160 170 180 190 200 210 pF1KSD VEKVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 VEKVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGE 190 200 210 220 230 240 220 230 240 250 260 270 pF1KSD GNLSRPAVQLLGDVMSEDGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 GNLSRPAVQLLGDVMSEDGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KSD GLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 GLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPR 310 320 330 340 350 360 340 350 360 370 380 390 pF1KSD HMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 HMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASY 370 380 390 400 410 420 400 410 420 430 440 450 pF1KSD TWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 TWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQP 430 440 450 460 470 480 460 470 480 490 500 510 pF1KSD PALWQTEKDDWTVPYGRIYFAGEHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 PALWQTEKDDWTVPYGRIYFAGEHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPE 490 500 510 520 530 540 520 530 540 550 560 pF1KSD GHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH ::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 GHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH 550 560 570 580 >>NP_001244946 (OMIM: 609742) L-amino-acid oxidase isofo (589 aa) initn: 3793 init1: 3793 opt: 3793 Z-score: 4390.9 bits: 822.4 E(85289): 0 Smith-Waterman score: 3793; 99.6% identity (99.8% similar) in 565 aa overlap (3-567:25-589) 10 20 30 pF1KSD MAPLALHLLVLVPILLSLVASQDWKAERSQDPFEKCMQ : .::::::::::::::::::::::::::::::::: NP_001 MPNDDFCPGLTIKAMGAERAPQRQPCTLHLLVLVPILLSLVASQDWKAERSQDPFEKCMQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KSD DPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRI 70 80 90 100 110 120 100 110 120 130 140 150 pF1KSD FTYRDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTYRDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYV 130 140 150 160 170 180 160 170 180 190 200 210 pF1KSD VEKVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEKVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKAMKKFERHTLLEYLLGE 190 200 210 220 230 240 220 230 240 250 260 270 pF1KSD GNLSRPAVQLLGDVMSEDGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNLSRPAVQLLGDVMSEDGFFYLSFAEALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KSD GLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAVKRITFSPPLPR 310 320 330 340 350 360 340 350 360 370 380 390 pF1KSD HMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGHSNTDRPSRMIFYPPPREGALLLASY 370 380 390 400 410 420 400 410 420 430 440 450 pF1KSD TWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQP 430 440 450 460 470 480 460 470 480 490 500 510 pF1KSD PALWQTEKDDWTVPYGRIYFAGEHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PALWQTEKDDWTVPYGRIYFAGEHTAYPHGWVETAVKSALRAAIKINSRKGPASDTASPE 490 500 510 520 530 540 520 530 540 550 560 pF1KSD GHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH 550 560 570 580 >>NP_000889 (OMIM: 309860) amine oxidase [flavin-contain (520 aa) initn: 350 init1: 197 opt: 400 Z-score: 462.2 bits: 95.3 E(85289): 5.3e-19 Smith-Waterman score: 415; 24.6% identity (55.3% similar) in 488 aa overlap (62-527:7-475) 40 50 60 70 80 90 pF1KSD PFEKCMQDPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEAD :.:::.:..:..:::.: :.: .:..::: NP_000 MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEAR 10 20 30 100 110 120 130 140 150 pF1KSD NRIGGRIFTYRDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHE .:.::: .: :.:.. .. :.. :...::: .: . :::. : .. .. .:. NP_000 DRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRIL-RLAKELGLETYKVNEVER----LIHH 40 50 60 70 80 90 160 170 180 190 200 pF1KSD VKLRNYVVEKVPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKA--MKKFERH :: ..: : . . . . .. . .... ... . . :: .... NP_000 VKGKSY-----PFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNM 100 110 120 130 140 210 220 230 240 250 pF1KSD TLLEYLLGEGNLSRPAVQL---------LGDVMSEDGFFYLSFAEALRAHSCL---SDRL :. : :: . .. : :: ... .....: ... . . . .. NP_000 TMKE-LLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGG 150 160 170 180 190 200 260 270 280 290 300 310 pF1KSD QYSRIVGGWDLLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADV : ..::: . . ... :. : :. ::. . : ..: :. . : .. .: NP_000 QERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVE------TLNHEMYEAKY 210 220 230 240 250 320 330 340 350 360 370 pF1KSD VLLTASGPAVK-RITFSPPLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGH--S :. .: :.. .: :.:::: .. . :. . : .. ...::::.. : . NP_000 VI-SAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIID 260 270 280 290 300 310 380 390 400 410 420 430 pF1KSD NTDRPSRMIFYPPPREGALL-LASYTWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQ . . : . . :: . .. . : .: :..:: :. . : . : . . NP_000 GEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSL-EA 320 330 340 350 360 370 440 450 460 470 480 490 pF1KSD LWDGTGVVKRWAEDQHSQGGFVVQ-PPALWQTEKDDWTVPYGRIYFAGEHTA-YPHGWVE : : : :.:.: : ... ::.. : :::::: .:: . :..: NP_000 LEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYME 380 390 400 410 420 430 500 510 520 530 540 pF1KSD TAVKSALRAAIKINSRKG--PASDTASPEGHASDMEGQGHVHGVASSPSHDLAKEEGSHP ::... ::: .: : : .. . : .. :. .: NP_000 GAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIG 440 450 460 470 480 490 550 560 pF1KSD PVQGQLSLQNTTHTRTSH NP_000 LTTIFSATALGFLAHKRGLLVRV 500 510 520 >>NP_000231 (OMIM: 300615,309850) amine oxidase [flavin- (527 aa) initn: 331 init1: 189 opt: 356 Z-score: 411.1 bits: 85.8 E(85289): 3.7e-16 Smith-Waterman score: 365; 25.3% identity (52.2% similar) in 490 aa overlap (62-513:16-468) 40 50 60 70 80 90 pF1KSD PFEKCMQDPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEAD :.:.:.:..:: :::.:.. : .: .::: NP_000 MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEAR 10 20 30 40 100 110 120 130 140 pF1KSD NRIGGRIFTYRDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTK------FTQYDKN- .:.::: .: :.... .. ::. :...::: .: . ::.. : ..:: :. NP_000 DRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRIL-RLSKELGIETYKVNVSERLVQYVKGK 50 60 70 80 90 100 150 160 170 180 190 pF1KSD ----------TWTEVHEVKLRNYVVEKVPEKLGYAL---RPQEKGHSPEDIYQMALNQAL .:. . . : . .. ...: . : : :. : .. .... NP_000 TYPFRGAFPPVWNPIAYLDYNN--LWRTIDNMGKEIPTDAPWEAQHA--DKWD---KMTM 110 120 130 140 150 200 210 220 230 240 pF1KSD KDLKALGC-RKAMKKFERHTLLEYLLGEGNL-SRP----AVQLLGDVMSEDGFFYLSFAE :.: : :. ..: ::. . :. :.: :. .: : . : NP_000 KELIDKICWTKTARRFA------YLFVNINVTSEPHEVSALWFLWYVKQCGG-------- 160 170 180 190 200 250 260 270 280 290 300 pF1KSD ALRAHSCLSDRLQYSRIVGGWDLLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQIETSP . : : ... : ..::: . . ... :. : :: ::. . :. .. .. . NP_000 TTRIFS-VTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHE 210 220 230 240 250 260 310 320 330 340 350 360 pF1KSD PARNLKVLKADVVLLTASGPAVKRITFSPPLPRHMQEALRRLHYVPATKVFLSFRRPFWR . :..: ::: .: : : :: . .. ..:: . . : .. ... ::. NP_000 HYECKYVINAIPPTLTA------KIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWK 270 280 290 300 310 370 380 390 400 410 pF1KSD EEHIEGGH--SNTDRPSRMIFYPPPREGAL-LLASYTWSDAAAAFAGLSRE-------EA .. : . : : . . .:.: . .. . : .: : .: : NP_000 KKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICEL 320 330 340 350 360 370 420 430 440 450 460 470 pF1KSD LRLALDDVAALHGPVVRQLWDGTGVVKRWAEDQHSQGGFVVQ-PPALWQTEKDDWTVPYG .: . ::: :: . : : :.:.: : ... ::.. : : NP_000 YAKVLGSQEALH-PVHYEE-------KNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVG 380 390 400 410 420 480 490 500 510 520 530 pF1KSD RIYFAGEHTAYP-HGWVETAVKSALRAAIKINSRKGPASDTASPEGHASDMEGQGHVHGV ::.::: .:: :..: ::... ::: .. . : ... NP_000 RIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITH 430 440 450 460 470 480 540 550 560 pF1KSD ASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH NP_000 TFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS 490 500 510 520 >>XP_016885013 (OMIM: 309860) PREDICTED: amine oxidase [ (504 aa) initn: 302 init1: 149 opt: 352 Z-score: 406.8 bits: 85.0 E(85289): 6.4e-16 Smith-Waterman score: 367; 23.8% identity (54.4% similar) in 478 aa overlap (72-527:1-459) 50 60 70 80 90 100 pF1KSD YEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFTY ..:::.: :.: .:..::: .:.::: .: XP_016 MAAAKLLHDSGLNVVVLEARDRVGGRTYTL 10 20 30 110 120 130 140 150 160 pF1KSD RDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYVVEK :.:.. .. :.. :...::: .: . :::. : .. .. .:.:: ..: XP_016 RNQKVKYVDLGGSYVGPTQNRIL-RLAKELGLETYKVNEVER----LIHHVKGKSY---- 40 50 60 70 80 170 180 190 200 210 pF1KSD VPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKA--MKKFERHTLLEYLLGEG : . . . . .. . .... ... . . :: .... :. : :: . XP_016 -PFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKE-LLDKL 90 100 110 120 130 220 230 240 250 260 pF1KSD NLSRPAVQL---------LGDVMSEDGFFYLSFAEALRAHSCL---SDRLQYSRIVGGWD .. : :: ... .....: ... . . . .. : ..::: XP_016 CWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSG 140 150 160 170 180 190 270 280 290 300 310 320 pF1KSD LLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAV . . ... :. : :. ::. . : ..: :. . : .. .: :. .: :.. XP_016 QVSERIMDLLGDRVKLERPVIYIDQTRENVLVE------TLNHEMYEAKYVI-SAIPPTL 200 210 220 230 240 250 330 340 350 360 370 380 pF1KSD K-RITFSPPLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGH--SNTDRPSRMIF .: :.:::: .. . :. . : .. ...::::.. : .. . : . . XP_016 GMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTL 260 270 280 290 300 310 390 400 410 420 430 440 pF1KSD YPPPREGALL-LASYTWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKR :: . .. . : .: :..:: :. . : . : . . : : XP_016 DDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSL-EALEPVHYEEKN 320 330 340 350 360 370 450 460 470 480 490 500 pF1KSD WAEDQHSQGGFVVQ-PPALWQTEKDDWTVPYGRIYFAGEHTA-YPHGWVETAVKSALRAA : :.:.: : ... ::.. : :::::: .:: . :..: ::... ::: XP_016 WCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAA 380 390 400 410 420 430 510 520 530 540 550 pF1KSD IKINSRKG--PASDTASPEGHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQN .: : : .. . : .. :. .: XP_016 REILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATAL 440 450 460 470 480 490 >>XP_005272665 (OMIM: 309860) PREDICTED: amine oxidase [ (504 aa) initn: 302 init1: 149 opt: 352 Z-score: 406.8 bits: 85.0 E(85289): 6.4e-16 Smith-Waterman score: 367; 23.8% identity (54.4% similar) in 478 aa overlap (72-527:1-459) 50 60 70 80 90 100 pF1KSD YEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFTY ..:::.: :.: .:..::: .:.::: .: XP_005 MAAAKLLHDSGLNVVVLEARDRVGGRTYTL 10 20 30 110 120 130 140 150 160 pF1KSD RDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYVVEK :.:.. .. :.. :...::: .: . :::. : .. .. .:.:: ..: XP_005 RNQKVKYVDLGGSYVGPTQNRIL-RLAKELGLETYKVNEVER----LIHHVKGKSY---- 40 50 60 70 80 170 180 190 200 210 pF1KSD VPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKA--MKKFERHTLLEYLLGEG : . . . . .. . .... ... . . :: .... :. : :: . XP_005 -PFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKE-LLDKL 90 100 110 120 130 220 230 240 250 260 pF1KSD NLSRPAVQL---------LGDVMSEDGFFYLSFAEALRAHSCL---SDRLQYSRIVGGWD .. : :: ... .....: ... . . . .. : ..::: XP_005 CWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSG 140 150 160 170 180 190 270 280 290 300 310 320 pF1KSD LLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAV . . ... :. : :. ::. . : ..: :. . : .. .: :. .: :.. XP_005 QVSERIMDLLGDRVKLERPVIYIDQTRENVLVE------TLNHEMYEAKYVI-SAIPPTL 200 210 220 230 240 250 330 340 350 360 370 380 pF1KSD K-RITFSPPLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGH--SNTDRPSRMIF .: :.:::: .. . :. . : .. ...::::.. : .. . : . . XP_005 GMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTL 260 270 280 290 300 310 390 400 410 420 430 440 pF1KSD YPPPREGALL-LASYTWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKR :: . .. . : .: :..:: :. . : . : . . : : XP_005 DDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSL-EALEPVHYEEKN 320 330 340 350 360 370 450 460 470 480 490 500 pF1KSD WAEDQHSQGGFVVQ-PPALWQTEKDDWTVPYGRIYFAGEHTA-YPHGWVETAVKSALRAA : :.:.: : ... ::.. : :::::: .:: . :..: ::... ::: XP_005 WCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAA 380 390 400 410 420 430 510 520 530 540 550 pF1KSD IKINSRKG--PASDTASPEGHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQN .: : : .. . : .. :. .: XP_005 REILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATAL 440 450 460 470 480 490 >>XP_016885012 (OMIM: 309860) PREDICTED: amine oxidase [ (504 aa) initn: 302 init1: 149 opt: 352 Z-score: 406.8 bits: 85.0 E(85289): 6.4e-16 Smith-Waterman score: 367; 23.8% identity (54.4% similar) in 478 aa overlap (72-527:1-459) 50 60 70 80 90 100 pF1KSD YEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDAGHKVTILEADNRIGGRIFTY ..:::.: :.: .:..::: .:.::: .: XP_016 MAAAKLLHDSGLNVVVLEARDRVGGRTYTL 10 20 30 110 120 130 140 150 160 pF1KSD RDQNTGWIGELGAMRMPSSHRILHKLCQGLGLNLTKFTQYDKNTWTEVHEVKLRNYVVEK :.:.. .. :.. :...::: .: . :::. : .. .. .:.:: ..: XP_016 RNQKVKYVDLGGSYVGPTQNRIL-RLAKELGLETYKVNEVER----LIHHVKGKSY---- 40 50 60 70 80 170 180 190 200 210 pF1KSD VPEKLGYALRPQEKGHSPEDIYQMALNQALKDLKALGCRKA--MKKFERHTLLEYLLGEG : . . . . .. . .... ... . . :: .... :. : :: . XP_016 -PFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKE-LLDKL 90 100 110 120 130 220 230 240 250 260 pF1KSD NLSRPAVQL---------LGDVMSEDGFFYLSFAEALRAHSCL---SDRLQYSRIVGGWD .. : :: ... .....: ... . . . .. : ..::: XP_016 CWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSG 140 150 160 170 180 190 270 280 290 300 310 320 pF1KSD LLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQIETSPPARNLKVLKADVVLLTASGPAV . . ... :. : :. ::. . : ..: :. . : .. .: :. .: :.. XP_016 QVSERIMDLLGDRVKLERPVIYIDQTRENVLVE------TLNHEMYEAKYVI-SAIPPTL 200 210 220 230 240 250 330 340 350 360 370 380 pF1KSD K-RITFSPPLPRHMQEALRRLHYVPATKVFLSFRRPFWREEHIEGGH--SNTDRPSRMIF .: :.:::: .. . :. . : .. ...::::.. : .. . : . . XP_016 GMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTL 260 270 280 290 300 310 390 400 410 420 430 440 pF1KSD YPPPREGALL-LASYTWSDAAAAFAGLSREEALRLALDDVAALHGPVVRQLWDGTGVVKR :: . .. . : .: :..:: :. . : . : . . : : XP_016 DDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSL-EALEPVHYEEKN 320 330 340 350 360 370 450 460 470 480 490 500 pF1KSD WAEDQHSQGGFVVQ-PPALWQTEKDDWTVPYGRIYFAGEHTA-YPHGWVETAVKSALRAA : :.:.: : ... ::.. : :::::: .:: . :..: ::... ::: XP_016 WCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAA 380 390 400 410 420 430 510 520 530 540 550 pF1KSD IKINSRKG--PASDTASPEGHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQN .: : : .. . : .. :. .: XP_016 REILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATAL 440 450 460 470 480 490 >>NP_787034 (OMIM: 615854) spermine oxidase isoform 2 [H (502 aa) initn: 251 init1: 98 opt: 233 Z-score: 269.0 bits: 59.5 E(85289): 3e-08 Smith-Waterman score: 250; 25.7% identity (50.0% similar) in 502 aa overlap (52-499:18-489) 30 40 50 60 70 80 pF1KSD QDWKAERSQDPFEKCMQDPDYEQLLKVVTWGLNRTLKPQRVIVVGAGVAGLVAAKVLSDA :: : .: ::.:.:::.:::.:::.: . NP_787 MQSCESSGDSADDPLSRGLRRRGQP-RVVVIGAGLAGLAAAKALLEQ 10 20 30 40 90 100 110 120 130 pF1KSD GHK-VTILEADNRIGGRIFTYRDQNTGWIGELGAMRMPSSH-RILHKLCQGLGLNLTKFT : ::.:::...::::. . . .. . :::: . .:: ...: .. :: : . : NP_787 GFTDVTVLEASSHIGGRVQSVKLGHATF--ELGATWIHGSHGNPIYHLAEANGL-LEETT 50 60 70 80 90 100 140 150 160 170 180 190 pF1KSD QYDKNTWTEVHEVKLRNYVVEKVPEKLGYALRPQEKGHS-PEDIYQMALNQALKDLKALG . ... : ...: . : : : ..:. :.:. . ..:: NP_787 DGERS----VGRISLYS--------KNGVACYLTNHGRRIPKDVVE-----EFSDLYNE- 110 120 130 140 200 210 220 230 240 250 pF1KSD CRKAMKKFERHTL---LEYLLGEGNLSRPAVQ--LLGDVMSEDGFFYLSFA---EALRAH . ..: :: : . : ..: :. . .: . .. :..: . :... NP_787 VYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLKLAMIQQYLKVE 150 160 170 180 190 200 260 270 280 290 300 pF1KSD SCLSDRLQYSRI----VGGWDLLPRALLSSLSGLVLLNAPVVAMTQGPHDVHVQIETSPP :: :. ..... : : .: : ::.. :: . .:: :. . : NP_787 SCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFMR----VVELLAEGIPAHV-IQLGKP 210 220 230 240 250 260 310 320 330 340 350 pF1KSD ARNLKVLKADVVLLTASGPAV------KRIT---FSPPLPRHMQEALRRLHYVPATKVFL .: .. .:.. :: . :: : : :: . :..:: . :.:: NP_787 VRCIHWDQASA---RPRGPEIEPRGVLKRQYTSFFRPGLPTEKVAAIHRLGIGTTDKIFL 270 280 290 300 310 360 370 380 390 400 410 pF1KSD SFRRPFWREEHIEGGHSNTDRP-SRMIFYPPP---REGALLLASYTWSDAAAAFAG-LSR :..::: : :. :. . ::: :. . . : . ...: . NP_787 EFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICG 320 330 340 350 360 370 420 430 440 450 460 pF1KSD EEALRLA-LDD--VAALHGPVVRQLWDGTGVVK-------RWAEDQHSQGGFVVQP--PA :::: . :: :: . ..::. . .. : :. . . .:.. . NP_787 EEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSS 380 390 400 410 420 430 470 480 490 500 pF1KSD LWQTEKDDWTVPYG--------RIYFAGE--HTAY---PHGWVETAVKSALRAAIKINSR ..:: .:: .. :.:: : : :: . .. . : : NP_787 GADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDL 440 450 460 470 480 490 510 520 530 540 550 560 pF1KSD KGPASDTASPEGHASDMEGQGHVHGVASSPSHDLAKEEGSHPPVQGQLSLQNTTHTRTSH NP_787 FQQGT 500 567 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 08:54:00 2016 done: Thu Nov 3 08:54:01 2016 Total Scan time: 9.870 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]