Result of FASTA (omim) for
pF1KSDF0183
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDF0183, 226 aa
1>>>pF1KSDF0183 226 - 226 aa - 226 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8361+/-0.000304; mu= 13.5826+/- 0.019
mean_var=99.8751+/-20.474, 0's: 0 Z-trim(119.5): 32 B-trim: 1548 in 1/52
Lambda= 0.128335
statistics sampled from 33589 (33621) to 33589 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.394), width: 16
Scan time: 5.650
The best scores are: opt bits E(85289)
NP_001034666 (OMIM: 613482) cyclin-L2 isoform B [H ( 226) 1477 282.9 3e-76
NP_112199 (OMIM: 613482) cyclin-L2 isoform A [Homo ( 520) 1442 276.7 5e-74
NP_001295114 (OMIM: 613384) cyclin-L1 isoform 2 [H ( 428) 1057 205.4 1.2e-52
XP_006713773 (OMIM: 613384) PREDICTED: cyclin-L1 i ( 493) 1057 205.4 1.4e-52
NP_064703 (OMIM: 613384) cyclin-L1 isoform 1 [Homo ( 526) 1057 205.5 1.4e-52
XP_016857912 (OMIM: 613482) PREDICTED: cyclin-L2 i ( 260) 778 153.5 3e-37
XP_011540518 (OMIM: 613482) PREDICTED: cyclin-L2 i ( 553) 778 153.8 5.3e-37
XP_011511313 (OMIM: 613384) PREDICTED: cyclin-L1 i ( 371) 380 80.0 6e-15
XP_005247705 (OMIM: 613384) PREDICTED: cyclin-L1 i ( 371) 380 80.0 6e-15
NP_001092872 (OMIM: 603544) cyclin-K [Homo sapiens ( 580) 266 59.0 1.9e-08
XP_005268211 (OMIM: 603544) PREDICTED: cyclin-K is ( 580) 266 59.0 1.9e-08
XP_011535577 (OMIM: 603544) PREDICTED: cyclin-K is ( 580) 266 59.0 1.9e-08
NP_001264771 (OMIM: 143055) cyclin-T1 isoform b [H ( 184) 253 56.2 4.2e-08
NP_001231 (OMIM: 143055) cyclin-T1 isoform a [Homo ( 726) 252 56.5 1.4e-07
NP_001232 (OMIM: 603862) cyclin-T2 isoform a [Homo ( 663) 249 55.9 1.9e-07
NP_490595 (OMIM: 603862) cyclin-T2 isoform b [Homo ( 730) 249 56.0 2e-07
NP_001124469 (OMIM: 300707,300708) cyclin-related ( 228) 241 54.1 2.3e-07
NP_689487 (OMIM: 300707,300708) cyclin-related pro ( 248) 241 54.1 2.5e-07
XP_011529516 (OMIM: 300707,300708) PREDICTED: cycl ( 206) 220 50.1 3.2e-06
XP_011529517 (OMIM: 300707,300708) PREDICTED: cycl ( 206) 220 50.1 3.2e-06
XP_005277978 (OMIM: 300707,300708) PREDICTED: cycl ( 218) 207 47.8 1.8e-05
XP_005277977 (OMIM: 300707,300708) PREDICTED: cycl ( 238) 207 47.8 1.9e-05
XP_016860717 (OMIM: 603862) PREDICTED: cyclin-T2 i ( 642) 193 45.6 0.00024
XP_016860716 (OMIM: 603862) PREDICTED: cyclin-T2 i ( 709) 193 45.6 0.00026
XP_006715657 (OMIM: 123838) PREDICTED: cyclin-C is ( 282) 165 40.1 0.0047
NP_005181 (OMIM: 123838) cyclin-C isoform a [Homo ( 283) 165 40.1 0.0047
>>NP_001034666 (OMIM: 613482) cyclin-L2 isoform B [Homo (226 aa)
initn: 1477 init1: 1477 opt: 1477 Z-score: 1489.9 bits: 282.9 E(85289): 3e-76
Smith-Waterman score: 1477; 100.0% identity (100.0% similar) in 226 aa overlap (1-226:1-226)
10 20 30 40 50 60
pF1KSD MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAE
130 140 150 160 170 180
190 200 210 220
pF1KSD RRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWVASEGK
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWVASEGK
190 200 210 220
>>NP_112199 (OMIM: 613482) cyclin-L2 isoform A [Homo sap (520 aa)
initn: 1442 init1: 1442 opt: 1442 Z-score: 1450.0 bits: 276.7 E(85289): 5e-74
Smith-Waterman score: 1442; 100.0% identity (100.0% similar) in 220 aa overlap (1-220:1-220)
10 20 30 40 50 60
pF1KSD MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 FTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 EHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAE
130 140 150 160 170 180
190 200 210 220
pF1KSD RRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWVASEGK
::::::::::::::::::::::::::::::::::::::::
NP_112 RRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWNYMNDSLRTDVFVRFQPESI
190 200 210 220 230 240
NP_112 ACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICLKILQLYARKKVDLTHLEGEVEK
250 260 270 280 290 300
>>NP_001295114 (OMIM: 613384) cyclin-L1 isoform 2 [Homo (428 aa)
initn: 1153 init1: 1031 opt: 1057 Z-score: 1065.9 bits: 205.4 E(85289): 1.2e-52
Smith-Waterman score: 1057; 72.1% identity (90.9% similar) in 219 aa overlap (3-220:7-225)
10 20 30 40 50
pF1KSD MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQG-VLIGDRLYSGVLITLENCLLP
..:.::.::.::::.:.... :. . . . : .:::::::: : .:... :.:
NP_001 MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD DDKLRFTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSF
...: ::::..::: .:::::..::::::::::::::::::::::::::.::::.:::
NP_001 EERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSF
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD VKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQ
::::.: :.:::..::::::::::::::::::::.::::: :. : ::.:::.:.: :::
NP_001 VKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQ
130 140 150 160 170 180
180 190 200 210 220
pF1KSD IIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWVASEGK
.::::::::::::::::::::::::::::::::::::: ::::.:
NP_001 VIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRF
190 200 210 220 230 240
NP_001 QPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLE
250 260 270 280 290 300
>>XP_006713773 (OMIM: 613384) PREDICTED: cyclin-L1 isofo (493 aa)
initn: 1151 init1: 1031 opt: 1057 Z-score: 1065.1 bits: 205.4 E(85289): 1.4e-52
Smith-Waterman score: 1057; 72.1% identity (90.9% similar) in 219 aa overlap (3-220:7-225)
10 20 30 40 50
pF1KSD MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQG-VLIGDRLYSGVLITLENCLLP
..:.::.::.::::.:.... :. . . . : .:::::::: : .:... :.:
XP_006 MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD DDKLRFTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSF
...: ::::..::: .:::::..::::::::::::::::::::::::::.::::.:::
XP_006 EERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSF
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD VKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQ
::::.: :.:::..::::::::::::::::::::.::::: :. : ::.:::.:.: :::
XP_006 VKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQ
130 140 150 160 170 180
180 190 200 210 220
pF1KSD IIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWVASEGK
.::::::::::::::::::::::::::::::::::::: ::::.:
XP_006 VIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRF
190 200 210 220 230 240
XP_006 QPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLE
250 260 270 280 290 300
>>NP_064703 (OMIM: 613384) cyclin-L1 isoform 1 [Homo sap (526 aa)
initn: 1151 init1: 1031 opt: 1057 Z-score: 1064.7 bits: 205.5 E(85289): 1.4e-52
Smith-Waterman score: 1057; 72.1% identity (90.9% similar) in 219 aa overlap (3-220:7-225)
10 20 30 40 50
pF1KSD MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQG-VLIGDRLYSGVLITLENCLLP
..:.::.::.::::.:.... :. . . . : .:::::::: : .:... :.:
NP_064 MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD DDKLRFTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSF
...: ::::..::: .:::::..::::::::::::::::::::::::::.::::.:::
NP_064 EERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSF
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD VKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQ
::::.: :.:::..::::::::::::::::::::.::::: :. : ::.:::.:.: :::
NP_064 VKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQ
130 140 150 160 170 180
180 190 200 210 220
pF1KSD IIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWVASEGK
.::::::::::::::::::::::::::::::::::::: ::::.:
NP_064 VIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRF
190 200 210 220 230 240
NP_064 QPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLE
250 260 270 280 290 300
>>XP_016857912 (OMIM: 613482) PREDICTED: cyclin-L2 isofo (260 aa)
initn: 1219 init1: 778 opt: 778 Z-score: 789.7 bits: 153.5 E(85289): 3e-37
Smith-Waterman score: 1154; 76.4% identity (79.1% similar) in 258 aa overlap (1-225:1-258)
10 20 30 40 50 60
pF1KSD MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSM
70 80 90 100 110 120
130 140 150
pF1KSD EHVSM---------------------ACVHLASKIEEAPRRIRDVINVFHRL-----RQL
: :. :::. :: . . :.
XP_016 EPSSLWRPSGRRGWGQTWACCNASASACVNGLCPPGFQDRRGPKTHTGRHQCVSPPSTAE
130 140 150 160 170 180
160 170 180 190 200
pF1KSD RDK-------KKPVPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVL
:.: .:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQKTLCSLSGRKPVPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVL
190 200 210 220 230 240
210 220
pF1KSD ECERNQHLVQTSWVASEGK
::::::::::::::::::
XP_016 ECERNQHLVQTSWVASEGIT
250 260
>>XP_011540518 (OMIM: 613482) PREDICTED: cyclin-L2 isofo (553 aa)
initn: 1190 init1: 778 opt: 778 Z-score: 785.3 bits: 153.8 E(85289): 5.3e-37
Smith-Waterman score: 1125; 75.9% identity (78.7% similar) in 253 aa overlap (1-220:1-253)
10 20 30 40 50 60
pF1KSD MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSM
70 80 90 100 110 120
130 140 150
pF1KSD EHVSM---------------------ACVHLASKIEEAPRRIRDVINVFHRL-----RQL
: :. :::. :: . . :.
XP_011 EPSSLWRPSGRRGWGQTWACCNASASACVNGLCPPGFQDRRGPKTHTGRHQCVSPPSTAE
130 140 150 160 170 180
160 170 180 190 200
pF1KSD RDK-------KKPVPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVL
:.: .:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQKTLCSLSGRKPVPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVL
190 200 210 220 230 240
210 220
pF1KSD ECERNQHLVQTSWVASEGK
:::::::::::::
XP_011 ECERNQHLVQTSWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLLFG
250 260 270 280 290 300
>>XP_011511313 (OMIM: 613384) PREDICTED: cyclin-L1 isofo (371 aa)
initn: 369 init1: 369 opt: 380 Z-score: 389.4 bits: 80.0 E(85289): 6e-15
Smith-Waterman score: 380; 82.8% identity (93.8% similar) in 64 aa overlap (157-220:7-70)
130 140 150 160 170 180
pF1KSD CVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAERRVLKE
.. : ::.:::.:.: :::.::::::::::
XP_011 MKLSSWQQTPSPLILDQNYINTKNQVIKAERRVLKE
10 20 30
190 200 210 220
pF1KSD LGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWVASEGK
::::::::::::::::::::::::::: ::::.:
XP_011 LGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRFQPETIACACIY
40 50 60 70 80 90
XP_011 LAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQ
100 110 120 130 140 150
>>XP_005247705 (OMIM: 613384) PREDICTED: cyclin-L1 isofo (371 aa)
initn: 369 init1: 369 opt: 380 Z-score: 389.4 bits: 80.0 E(85289): 6e-15
Smith-Waterman score: 380; 82.8% identity (93.8% similar) in 64 aa overlap (157-220:7-70)
130 140 150 160 170 180
pF1KSD CVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAERRVLKE
.. : ::.:::.:.: :::.::::::::::
XP_005 MKLSSWQQTPSPLILDQNYINTKNQVIKAERRVLKE
10 20 30
190 200 210 220
pF1KSD LGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWVASEGK
::::::::::::::::::::::::::: ::::.:
XP_005 LGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRFQPETIACACIY
40 50 60 70 80 90
XP_005 LAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQ
100 110 120 130 140 150
>>NP_001092872 (OMIM: 603544) cyclin-K [Homo sapiens] (580 aa)
initn: 242 init1: 181 opt: 266 Z-score: 272.7 bits: 59.0 E(85289): 1.9e-08
Smith-Waterman score: 266; 33.5% identity (63.0% similar) in 173 aa overlap (52-220:23-186)
30 40 50 60 70 80
pF1KSD APGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDK-LRFTPSMSSGLDTDTETDLRVV
: : : : :::. ::: ::. :
NP_001 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRRE
10 20 30 40 50
90 100 110 120 130
pF1KSD GCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMAC-VHLASKIEEAPR
: ..: .: : : ..::: . :.::.. .:: :. ..:. :: . ::.:.::.:.
NP_001 GARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSF-KQFPRYVTGACCLFLAGKVEETPK
60 70 80 90 100 110
140 150 160 170 180 190
pF1KSD RIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKI
. .:.:.. . : : : . . : . :.... :: .:. . : ..:.::...
NP_001 KCKDIIKTARSL--LNDVQ------FGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQF
120 130 140 150 160
200 210 220
pF1KSD IVMYLQVLECERN--QHLVQTSWVASEGK
.. : . :. ..: :.::: .:
NP_001 LLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQ
170 180 190 200 210 220
226 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 08:55:13 2016 done: Thu Nov 3 08:55:14 2016
Total Scan time: 5.650 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]