HUGE

Gene/Protein Characteristic Table for KIAA0279

Link to : Rouge \| GTOP \| SWISS-PROT/TrEMBL \| GeneCards\| RefDIC
Features : DNA sequence \| Protein sequence \| Expression \| Mapping

Product ID :	ORK04527
Accession No. :	D87469
Description :	Cadherin EGF LAG seven-pass G-type receptor 2 precursor.
HUGO Gene Name :	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) (CELSR2)
Clone Name :	ff05612 [Vector Info]
Source :	Human fetal brain
Note :	We replaced ha06133, former representative clones for KIAA0279 with ff05612. (2005/08/06)

Features of the cloned DNA sequence	Description

Length: 10267 bp
Physical map
Restriction map
Prediction of protein coding region (GeneMark analysis) for :
cloned DNA seq.
Warning for N-terminal truncation:
YES

Warning for coding interruption:
NO

Integrity of 3' end

Length of 3'UTR 1702 bp

Genome contig ID gi89161185f_109494432
PolyA signal sequence
(AATAAA,-22)
+----*----+----*----+----*----+----
CCCCATACTACTGAATAAACTAGTTCTGTGCGGGT
Flanking genome sequence
(125465 - 125514)
----+----*----+----*----+----*----+----*----+----*
ACAGCACTGTCACTGTCCGCTTCTGTGTGGTACCCTGTCCTCCCACAGGG

Ensembl ContigView (Add our DAS server as a DAS source)

Chr f/r start end exon identity class

ContigView(URL based/DAS) 1 f 109594432 109619895 34 99.4 Perfect prediction

Features of the protein sequence	Description

Length: 2854 aa

Result of homology search against nr database (FASTA output, Multiple alignment)

Entry	ID%	Protein	Source
Q9HCU4	100.0	Cadherin EGF LA...	Homo sapiens
EAW56372	100.0	cadherin, EGF L...	Homo sapiens
XP_537042	97.1	similar to cadh...	Canis lupus fam...
XP_001494282	97.3	cadherin, EGF L...	Equus caballus
XP_618390	96.5	similar to cadh...	Bos taurus

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of homology search against other HUGE database (FASTA output, Multiple alignment)

Entry	Exp	ID%	HUGE_ID
AB011536	9.4e-51	43.5	KIAA0812
AB058715	1.3e-25	35.2	KIAA1812
AB018311	1.3e-23	32.1	KIAA0768
AB011160	2.4e-22	31.3	KIAA0588
AB160984	3.6e-22	26.1	KIAA0811

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of motif / domain search (InterProScan and SOSUI)

[ zoom out (x2) ]

Result of InterProScan

Search method interpro_ID From To Entry Definition

FPrintScan IPR002126 161 180 PR00205 Cadherin

IPR002126 220 249 PR00205 Cadherin

IPR002126 293 305 PR00205 Cadherin

IPR002126 520 539 PR00205 Cadherin

IPR002126 539 552 PR00205 Cadherin

IPR002126 694 720 PR00205 Cadherin

IPR002126 728 745 PR00205 Cadherin

IPR000832 2309 2333 PR00249 GPCR

IPR000832 2372 2395 PR00249 GPCR

IPR000832 2410 2435 PR00249 GPCR

IPR000832 2452 2477 PR00249 GPCR

HMMPfam IPR002126 117 211 PF00028 Cadherin

IPR002126 225 321 PF00028 Cadherin

IPR002126 335 427 PF00028 Cadherin

IPR002126 441 532 PF00028 Cadherin

IPR002126 546 634 PF00028 Cadherin

IPR002126 648 737 PF00028 Cadherin

IPR002126 751 843 PF00028 Cadherin

IPR002126 857 945 PF00028 Cadherin

IPR006209 1163 1216 PF00008 EGF-like

IPR006209 1223 1254 PF00008 EGF-like

IPR006209 1263 1296 PF00008 EGF-like

IPR012680 1326 1485 PF02210 Laminin G

IPR006209 1509 1540 PF00008 EGF-like

IPR012680 1575 1701 PF02210 Laminin G

IPR006209 1728 1759 PF00008 EGF-like

IPR006209 1763 1797 PF00008 EGF-like

IPR002049 1855 1888 PF00053 EGF-like

IPR001879 1904 1961 PF02793 Hormone receptor

IPR000203 2246 2294 PF01825 GPS

IPR000832 2304 2547 PF00002 GPCR

HMMSmart IPR002126 134 218 SM00112 Cadherin

IPR002126 242 328 SM00112 Cadherin

IPR002126 352 434 SM00112 Cadherin

IPR002126 458 539 SM00112 Cadherin

IPR002126 563 641 SM00112 Cadherin

IPR002126 665 744 SM00112 Cadherin

IPR002126 768 850 SM00112 Cadherin

IPR002126 874 952 SM00112 Cadherin

IPR002126 980 1056 SM00112 Cadherin

IPR006210 1162 1217 SM00181 EGF

IPR001881 1219 1255 SM00179 EGF-like calcium-binding

IPR006210 1222 1255 SM00181 EGF

IPR006210 1262 1297 SM00181 EGF

IPR001881 1263 1297 SM00179 EGF-like calcium-binding

IPR001791 1318 1485 SM00282 Laminin G

IPR001881 1505 1541 SM00179 EGF-like calcium-binding

IPR006210 1508 1541 SM00181 EGF

IPR001791 1567 1701 SM00282 Laminin G

IPR001881 1726 1760 SM00179 EGF-like calcium-binding

IPR006210 1727 1760 SM00181 EGF

IPR006210 1762 1798 SM00181 EGF

IPR001881 1764 1798 SM00179 EGF-like calcium-binding

IPR002049 1855 1900 SM00180 EGF-like

IPR001879 1903 1965 SM00008 Hormone receptor

IPR000203 2246 2299 SM00303 GPS

ProfileScan IPR002126 113 220 PS50268 Cadherin

IPR002126 221 330 PS50268 Cadherin

IPR002126 331 436 PS50268 Cadherin

IPR002126 437 541 PS50268 Cadherin

IPR002126 542 643 PS50268 Cadherin

IPR002126 644 746 PS50268 Cadherin

IPR002126 747 852 PS50268 Cadherin

IPR002126 853 954 PS50268 Cadherin

IPR002126 973 1077 PS50268 Cadherin

IPR000742 1159 1217 PS50026 EGF-like

IPR002049 1205 1265 PS50027 EGF-like

IPR000742 1219 1255 PS50026 EGF-like

IPR000742 1259 1297 PS50026 EGF-like

IPR001791 1298 1502 PS50025 Laminin G

IPR000742 1505 1541 PS50026 EGF-like

IPR001791 1545 1722 PS50025 Laminin G

IPR000742 1724 1760 PS50026 EGF-like

IPR000742 1761 1798 PS50026 EGF-like

IPR002049 1855 1902 PS50027 EGF-like

IPR001879 1887 1960 PS50227 Hormone receptor

IPR000203 2247 2299 PS50221 GPS

IPR000832 2307 2544 PS50261 GPCR

ScanRegExp IPR002126 208 218 PS00232 Cadherin

IPR002126 318 328 PS00232 Cadherin

IPR002126 424 434 PS00232 Cadherin

IPR002126 529 539 PS00232 Cadherin

IPR002126 734 744 PS00232 Cadherin

IPR002126 840 850 PS00232 Cadherin

IPR002126 942 952 PS00232 Cadherin

IPR013032 1205 1216 PS00022 EGF-like region

IPR013032 1205 1216 PS01186 EGF-like region

IPR013032 1243 1254 PS00022 EGF-like region

IPR013032 1243 1254 PS01186 EGF-like region

IPR000152 1520 1531 PS00010 Aspartic acid and asparagine hydroxylation site

IPR013032 1529 1540 PS00022 EGF-like region

IPR013032 1529 1540 PS01186 EGF-like region

IPR000152 1739 1750 PS00010 Aspartic acid and asparagine hydroxylation site

IPR013032 1748 1759 PS00022 EGF-like region

IPR013032 1748 1763 PS01186 EGF-like region

IPR013032 1786 1797 PS00022 EGF-like region

IPR013032 1874 1885 PS00022 EGF-like region

IPR002049 1874 1907 PS01248 EGF-like

Search method	interpro_ID	From	To	Entry	Definition
FPrintScan	IPR002126	161	180	PR00205	Cadherin
IPR002126	220	249	PR00205	Cadherin
IPR002126	293	305	PR00205	Cadherin
IPR002126	520	539	PR00205	Cadherin
IPR002126	539	552	PR00205	Cadherin
IPR002126	694	720	PR00205	Cadherin
IPR002126	728	745	PR00205	Cadherin
IPR000832	2309	2333	PR00249	GPCR
IPR000832	2372	2395	PR00249	GPCR
IPR000832	2410	2435	PR00249	GPCR
IPR000832	2452	2477	PR00249	GPCR
HMMPfam	IPR002126	117	211	PF00028	Cadherin
IPR002126	225	321	PF00028	Cadherin
IPR002126	335	427	PF00028	Cadherin
IPR002126	441	532	PF00028	Cadherin
IPR002126	546	634	PF00028	Cadherin
IPR002126	648	737	PF00028	Cadherin
IPR002126	751	843	PF00028	Cadherin
IPR002126	857	945	PF00028	Cadherin
IPR006209	1163	1216	PF00008	EGF-like
IPR006209	1223	1254	PF00008	EGF-like
IPR006209	1263	1296	PF00008	EGF-like
IPR012680	1326	1485	PF02210	Laminin G
IPR006209	1509	1540	PF00008	EGF-like
IPR012680	1575	1701	PF02210	Laminin G
IPR006209	1728	1759	PF00008	EGF-like
IPR006209	1763	1797	PF00008	EGF-like
IPR002049	1855	1888	PF00053	EGF-like
IPR001879	1904	1961	PF02793	Hormone receptor
IPR000203	2246	2294	PF01825	GPS
IPR000832	2304	2547	PF00002	GPCR
HMMSmart	IPR002126	134	218	SM00112	Cadherin
IPR002126	242	328	SM00112	Cadherin
IPR002126	352	434	SM00112	Cadherin
IPR002126	458	539	SM00112	Cadherin
IPR002126	563	641	SM00112	Cadherin
IPR002126	665	744	SM00112	Cadherin
IPR002126	768	850	SM00112	Cadherin
IPR002126	874	952	SM00112	Cadherin
IPR002126	980	1056	SM00112	Cadherin
IPR006210	1162	1217	SM00181	EGF
IPR001881	1219	1255	SM00179	EGF-like calcium-binding
IPR006210	1222	1255	SM00181	EGF
IPR006210	1262	1297	SM00181	EGF
IPR001881	1263	1297	SM00179	EGF-like calcium-binding
IPR001791	1318	1485	SM00282	Laminin G
IPR001881	1505	1541	SM00179	EGF-like calcium-binding
IPR006210	1508	1541	SM00181	EGF
IPR001791	1567	1701	SM00282	Laminin G
IPR001881	1726	1760	SM00179	EGF-like calcium-binding
IPR006210	1727	1760	SM00181	EGF
IPR006210	1762	1798	SM00181	EGF
IPR001881	1764	1798	SM00179	EGF-like calcium-binding
IPR002049	1855	1900	SM00180	EGF-like
IPR001879	1903	1965	SM00008	Hormone receptor
IPR000203	2246	2299	SM00303	GPS
ProfileScan	IPR002126	113	220	PS50268	Cadherin
IPR002126	221	330	PS50268	Cadherin
IPR002126	331	436	PS50268	Cadherin
IPR002126	437	541	PS50268	Cadherin
IPR002126	542	643	PS50268	Cadherin
IPR002126	644	746	PS50268	Cadherin
IPR002126	747	852	PS50268	Cadherin
IPR002126	853	954	PS50268	Cadherin
IPR002126	973	1077	PS50268	Cadherin
IPR000742	1159	1217	PS50026	EGF-like
IPR002049	1205	1265	PS50027	EGF-like
IPR000742	1219	1255	PS50026	EGF-like
IPR000742	1259	1297	PS50026	EGF-like
IPR001791	1298	1502	PS50025	Laminin G
IPR000742	1505	1541	PS50026	EGF-like
IPR001791	1545	1722	PS50025	Laminin G
IPR000742	1724	1760	PS50026	EGF-like
IPR000742	1761	1798	PS50026	EGF-like
IPR002049	1855	1902	PS50027	EGF-like
IPR001879	1887	1960	PS50227	Hormone receptor
IPR000203	2247	2299	PS50221	GPS
IPR000832	2307	2544	PS50261	GPCR
ScanRegExp	IPR002126	208	218	PS00232	Cadherin
IPR002126	318	328	PS00232	Cadherin
IPR002126	424	434	PS00232	Cadherin
IPR002126	529	539	PS00232	Cadherin
IPR002126	734	744	PS00232	Cadherin
IPR002126	840	850	PS00232	Cadherin
IPR002126	942	952	PS00232	Cadherin
IPR013032	1205	1216	PS00022	EGF-like region
IPR013032	1205	1216	PS01186	EGF-like region
IPR013032	1243	1254	PS00022	EGF-like region
IPR013032	1243	1254	PS01186	EGF-like region
IPR000152	1520	1531	PS00010	Aspartic acid and asparagine hydroxylation site
IPR013032	1529	1540	PS00022	EGF-like region
IPR013032	1529	1540	PS01186	EGF-like region
IPR000152	1739	1750	PS00010	Aspartic acid and asparagine hydroxylation site
IPR013032	1748	1759	PS00022	EGF-like region
IPR013032	1748	1763	PS01186	EGF-like region
IPR013032	1786	1797	PS00022	EGF-like region
IPR013032	1874	1885	PS00022	EGF-like region
IPR002049	1874	1907	PS01248	EGF-like

Prediction of transmembrane (TM) segments

Method No. N terminal transmembrane region C terminal type length

SOSUI2 1 2309 TLTYVALGVTLAALLLTFFFLTL 2331 PRIMARY 23

2 2345 NLTAALGLAQLVFLLGINQADLP 2367 SECONDARY 23

3 2369 ACTVIAILLHFLYLCTFSWALLE 2391 PRIMARY 23

4 2410 MRFYYMLGWGVPAFITGLAVGL 2431 SECONDARY 22

5 2451 IWSFAGPVAFAVSMSVFLYILAA 2473 PRIMARY 23

6 2493 LQPSFAVLLLLSATWLLALLSVN 2515 PRIMARY 23

7 2526 ATCNCIQGPFIFLSYVVLSKEV 2547 SECONDARY 22

Method	No.	N terminal	transmembrane region	C terminal	type	length
SOSUI2	1	2309	TLTYVALGVTLAALLLTFFFLTL	2331	PRIMARY	23
2	2345	NLTAALGLAQLVFLLGINQADLP	2367	SECONDARY	23
3	2369	ACTVIAILLHFLYLCTFSWALLE	2391	PRIMARY	23
4	2410	MRFYYMLGWGVPAFITGLAVGL	2431	SECONDARY	22
5	2451	IWSFAGPVAFAVSMSVFLYILAA	2473	PRIMARY	23
6	2493	LQPSFAVLLLLSATWLLALLSVN	2515	PRIMARY	23
7	2526	ATCNCIQGPFIFLSYVVLSKEV	2547	SECONDARY	22

Expression profile	Description

: Northern blot Description

Northern blot	Description

RH mapping information	Description

Chromosome No.

: 1

Experimental conditions

Panel name	: Genebridge 4
Primer_f	: TGCTGGATGCTAACTTGATAC
Primer_r	: GTTTATTCAGTAGTATGGGGC
PCR product length	: 112 bp
PCR conditions	: 95 °C15 sec62 °C60 sec30 cycles

How to obtain KIAA clone(s) Back to the HUGE Protein Database homepage

	cloned DNA seq.
Warning for N-terminal truncation:	YES
Warning for coding interruption:	NO

Length of 3'UTR	1702 bp
Genome contig ID	gi89161185f_109494432
PolyA signal sequence (AATAAA,-22)	+--------+--------+----*----+---- CCCCATACTACTGAATAAACTAGTTCTGTGCGGGT
Flanking genome sequence (125465 - 125514)	----+--------+--------+--------+--------+----* ACAGCACTGTCACTGTCCGCTTCTGTGTGGTACCCTGTCCTCCCACAGGG

	Chr	f/r	start	end	exon	identity	class
ContigView(URL based/DAS)	1	f	109594432	109619895	34	99.4	Perfect prediction

Gene/Protein Characteristic Table for KIAA0279

Features of the cloned DNA sequence

Features of the protein sequence

Expression profile

RH mapping information