HUGE

Gene/Protein Characteristic Table for KIAA0358

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Features : DNA sequence \| Protein sequence \| Expression \| Mapping

Product ID :	ORK00059
Accession No. :	AB002356
Description :	MAP kinase-activating death domain protein.
HUGO Gene Name :	MAP-kinase activating death domain (MADD)
Clone Name :	hh00017 [Vector Info]
Flexi ORF Clone :	pF1KA0358
Source :	Human adult brain

Features of the cloned DNA sequence	Description

Length: 5942 bp
Physical map
Restriction map
Prediction of protein coding region (GeneMark analysis) for :
cloned DNA seq.
Warning for N-terminal truncation:
NO

Warning for coding interruption:
NO

Features of the protein sequence	Description

Length: 1584 aa

Result of homology search against nr database (FASTA output, Multiple alignment)

Entry	ID%	Protein	Source
EAW67936	100.0	MAP-kinase acti...	Homo sapiens
Q8WXG6	99.8	MAP kinase-acti...	Homo sapiens
AAL40265	99.5	insulinoma-gluc...	Homo sapiens
XP_001108263	98.7	similar to MAP-...	Macaca mulatta
XP_001107325	98.7	similar to MAP-...	Macaca mulatta

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of homology search against other HUGE database (FASTA output, Multiple alignment)

Entry	Exp	ID%	HUGE_ID
AB029014	2.4e-06	24.4	KIAA1091
AB051553	3.7e-05	25.3	KIAA1766
AB007945	3.9e-05	24.5	KIAA0476
AB020677	7.4e-05	27.1	KIAA0870
AB033103	0.00029	27.5	KIAA1277

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of motif / domain search (InterProScan and SOSUI)

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Result of InterProScan

Search method interpro_ID From To Entry Definition

HMMPfam IPR005113 11 101 PF03456 uDENN

IPR001194 175 405 PF02141 DENN

IPR005112 488 561 PF03455 dDENN

HMMSmart IPR005113 11 101 SM00800 uDENN

IPR001194 175 405 SM00799 DENN

IPR005112 488 558 SM00801 dDENN

ProfileScan IPR005113 11 107 PS50946 uDENN

IPR001194 175 405 PS50211 DENN

IPR005112 488 561 PS50947 dDENN

Search method	interpro_ID	From	To	Entry	Definition
HMMPfam	IPR005113	11	101	PF03456	uDENN
IPR001194	175	405	PF02141	DENN
IPR005112	488	561	PF03455	dDENN
HMMSmart	IPR005113	11	101	SM00800	uDENN
IPR001194	175	405	SM00799	DENN
IPR005112	488	558	SM00801	dDENN
ProfileScan	IPR005113	11	107	PS50946	uDENN
IPR001194	175	405	PS50211	DENN
IPR005112	488	561	PS50947	dDENN

Prediction of transmembrane (TM) segments

Method No. N terminal transmembrane region C terminal type length

SOSUI2 1 303 PLELLGVDACLQVLTCILLEHKV 325 PRIMARY 23

2 336 SMSVMAFVAMIYPLEYMFPVIPL 358 PRIMARY 23

3 369 LLLAPTPYIIGVPASFFLYKLDF 391 SECONDARY 23

Method	No.	N terminal	transmembrane region	C terminal	type	length
SOSUI2	1	303	PLELLGVDACLQVLTCILLEHKV	325	PRIMARY	23
2	336	SMSVMAFVAMIYPLEYMFPVIPL	358	PRIMARY	23
3	369	LLLAPTPYIIGVPASFFLYKLDF	391	SECONDARY	23

Expression profile	Description

: RT-PCR Description

Experimental conditions

Primer_f
: GAATGCTGACTCCTTGCTTGG

Primer_r
: TCAAGTAACCGAGGACAGAAC

PCR conditions
: 95 °C30 sec55 °C30 sec72 °C60 sec30 cycles

RT-PCR	Description

RH mapping information	Description

Chromosome No.

: 11

Experimental conditions

Panel name	: GeneBridge 4
Primer_f	: GAATGCTGACTCCTTGCTTGG
Primer_r	: TCAAGTAACCGAGGACAGAAC
PCR product length	: 100 bp
PCR conditions	: 95 °C15 sec64 °C60 sec30 cycles

How to obtain KIAA clone(s) Back to the HUGE Protein Database homepage

	cloned DNA seq.
Warning for N-terminal truncation:	NO
Warning for coding interruption:	NO

Gene/Protein Characteristic Table for KIAA0358

Features of the cloned DNA sequence

Features of the protein sequence

Expression profile

RH mapping information