HUGE

Gene/Protein Characteristic Table for KIAA1465

Link to : Rouge \| GTOP \| SWISS-PROT/TrEMBL \| GeneCards\| RefDIC
Features : DNA sequence \| Protein sequence \| Expression \| Mapping

Product ID :	ORK00844
Accession No. :	AB040898
Description :	immunoglobulin superfamily containing leucine-rich repeat 2.
HUGO Gene Name :	immunoglobulin superfamily containing leucine-rich repeat 2 (ISLR2)
Clone Name :	fh13187 [Vector Info]
Flexi ORF Clone :	pF1KSDA1465
Source :	Human fetal brain
Note :	We replaced fj00601, former representative clones for KIAA1465 with fh13187. (2002/5/10)

Features of the cloned DNA sequence	Description

Length: 4815 bp
Physical map
Restriction map
Prediction of protein coding region (GeneMark analysis) for :
cloned DNA seq.
Warning for N-terminal truncation:
NO

Warning for coding interruption:
NO

Integrity of 3' end

Length of 3'UTR 1808 bp

Genome contig ID gi51511731f_72108768
PolyA signal sequence
(AATAAA,-18)
+----*----+----*----+----*----+----
CGCGTCTGTATGCAGTCAATAAAACAATCGATTTG
Flanking genome sequence
(107428 - 107477)
----+----*----+----*----+----*----+----*----+----*
AACTGGGCTCGGTGACTTTTTGTCAGGGGACAGAGGGAGGAGGCCTGGGC

Ensembl ContigView (Add our DAS server as a DAS source)

Chr f/r start end exon identity class

ContigView(URL based/DAS) 15 f 72208768 72216194 4 100.0 Perfect prediction

Features of the protein sequence	Description

Length: 785 aa

Result of homology search against nr database (FASTA output, Multiple alignment)

Entry	ID%	Protein	Source
Q6UXK2	100.0	Immunoglobulin ...	Homo sapiens
BAF83156	99.9	unnamed protein...	Homo sapiens
BAG53336	99.9	unnamed protein...	Homo sapiens
BAG52525	99.7	unnamed protein...	Homo sapiens
XP_001096467	97.5	similar to slit...	Macaca mulatta

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of homology search against other HUGE database (FASTA output, Multiple alignment)

Entry	Exp	ID%	HUGE_ID
D86983	1.8e-10	28.4	KIAA0230
AB011537	2e-09	28.6	KIAA0813
AB011538	2.1e-08	31.4	KIAA0814
AB007865	1.6e-07	26.2	KIAA0405
AB067491	6.7e-07	26.4	KIAA1904

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.

Result of motif / domain search (InterProScan and SOSUI)

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Result of InterProScan

Search method interpro_ID From To Entry Definition

FPrintScan IPR001611 141 154 PR00019 Leucine-rich repeat

IPR001611 162 175 PR00019 Leucine-rich repeat

HMMPfam IPR001611 92 114 PF00560 Leucine-rich repeat

IPR001611 116 138 PF00560 Leucine-rich repeat

IPR001611 140 162 PF00560 Leucine-rich repeat

IPR001611 164 186 PF00560 Leucine-rich repeat

IPR001611 188 210 PF00560 Leucine-rich repeat

IPR000483 248 271 PF01463 Cysteine-rich flanking region

IPR013098 281 412 PF07679 Immunoglobulin I-set

HMMSmart IPR003591 89 113 SM00369 Leucine-rich repeat

IPR003591 114 137 SM00369 Leucine-rich repeat

IPR003591 138 161 SM00369 Leucine-rich repeat

IPR003591 162 185 SM00369 Leucine-rich repeat

IPR003591 186 209 SM00369 Leucine-rich repeat

IPR000483 221 271 SM00082 Cysteine-rich flanking region

ProfileScan IPR007110 273 411 PS50835 Immunoglobulin-like

Search method	interpro_ID	From	To	Entry	Definition
FPrintScan	IPR001611	141	154	PR00019	Leucine-rich repeat
IPR001611	162	175	PR00019	Leucine-rich repeat
HMMPfam	IPR001611	92	114	PF00560	Leucine-rich repeat
IPR001611	116	138	PF00560	Leucine-rich repeat
IPR001611	140	162	PF00560	Leucine-rich repeat
IPR001611	164	186	PF00560	Leucine-rich repeat
IPR001611	188	210	PF00560	Leucine-rich repeat
IPR000483	248	271	PF01463	Cysteine-rich flanking region
IPR013098	281	412	PF07679	Immunoglobulin I-set
HMMSmart	IPR003591	89	113	SM00369	Leucine-rich repeat
IPR003591	114	137	SM00369	Leucine-rich repeat
IPR003591	138	161	SM00369	Leucine-rich repeat
IPR003591	162	185	SM00369	Leucine-rich repeat
IPR003591	186	209	SM00369	Leucine-rich repeat
IPR000483	221	271	SM00082	Cysteine-rich flanking region
ProfileScan	IPR007110	273	411	PS50835	Immunoglobulin-like

Prediction of transmembrane (TM) segments

Method No. N terminal transmembrane region C terminal type length

SOSUI2 1 1 GHNTCVYLAWAIFPALP 17 SECONDARY 17

2 36 ILGAAMFPLRALWLVWALLGVAG 58 PRIMARY 23

3 633 IVAVSVFLLVLATVPLLGAACCH 655 PRIMARY 23

Method	No.	N terminal	transmembrane region	C terminal	type	length
SOSUI2	1	1	GHNTCVYLAWAIFPALP	17	SECONDARY	17
2	36	ILGAAMFPLRALWLVWALLGVAG	58	PRIMARY	23
3	633	IVAVSVFLLVLATVPLLGAACCH	655	PRIMARY	23

Expression profile	Description

: RT-PCR-ELISA Description
: Experimental conditions

Primer_f
: TGTTACACTGCATCGCCGACG

Primer_r
: GCGTCAGCAAATCCCCATCTC

PCR conditions
: 95 °C30 sec55 °C30 sec72 °C60 sec30 cycles

RT-PCR-ELISA	Description

RH mapping information	Description

Chromosome No.

: 15

Experimental conditions

Panel name	: CCR
Primer_f	: TGTTACACTGCATCGCCGACG
Primer_r	: GCGTCAGCAAATCCCCATCTC
PCR product length	: 162 bp
PCR conditions	: 95 °C15 sec66 °C60 sec30 cycles

How to obtain KIAA clone(s) Back to the HUGE Protein Database homepage

	cloned DNA seq.
Warning for N-terminal truncation:	NO
Warning for coding interruption:	NO

Length of 3'UTR	1808 bp
Genome contig ID	gi51511731f_72108768
PolyA signal sequence (AATAAA,-18)	+--------+--------+----*----+---- CGCGTCTGTATGCAGTCAATAAAACAATCGATTTG
Flanking genome sequence (107428 - 107477)	----+--------+--------+--------+--------+----* AACTGGGCTCGGTGACTTTTTGTCAGGGGACAGAGGGAGGAGGCCTGGGC

	Chr	f/r	start	end	exon	identity	class
ContigView(URL based/DAS)	15	f	72208768	72216194	4	100.0	Perfect prediction

Gene/Protein Characteristic Table for KIAA1465

Features of the cloned DNA sequence

Features of the protein sequence

Expression profile

RH mapping information